Roland Klassen - Forschungsinformationssystem | Universität Kassel

Dr. Roland Klassen

Research Areas

Mathematics, Natural Sciences

Research Interest

Hefegenetik, non-conventional yeasts, Ribotoxine, tRNA Modifikation, tRNA Reparatur, DNA Reparatur, Mutagenese, DNA Polymerasen, Antimykotika

Academic background

10.1994-03.2000 Studium der Biologie (WWU Münster)

04.2000-10.2004 Promotion im Fachbereich Mikrobiologie (WWU Münster)

Projects as Principal Investigator

12/2015 - 11/2018

Functional cross-talk among modifications in the tRNA anticodon stem-loop

Publications

3 of 5

2016	Klassen, R., Ciftci, A., Funk, J., Bruch, A., Butter, F., Schaffrath, R., 2016. tRNA anticodon loop modifications ensure protein homeostasis and cell morphogenesis in yeast. Nucleic Acids Research 44, 10946–10959. https://doi.org/10.1093/nar/gkw705
2015	Kast, A., Voges, R., Schröder, M., Schaffrath, R., Klassen, R., Meinhardt, F., 2015. Auto-selection of cytoplasmic yeast virus like elements encoding toxin/anti-toxin systems involves a nuclear barrier for immunity gene expression. PLoS Genetics 11, e1005005. https://doi.org/10.1371/journal.pgen.1005005
2015	Klassen, R., Grunewald, P., Thüring, K.L., Eichler, C., Helm, M., Schaffrath, R., 2015. Loss of anticodon wobble uridine modifications affects tRNALys function and protein levels in Saccharomyces cerevisiae. PLoS ONE 10, e0119261. https://doi.org/10.1371/journal.pone.0119261
2015	Jüdes, A., Ebert, F., Bär, C., Thüring, K.L., Harrer, A., Klassen, R., Helm, M., Stark, M., Schaffrath, R., 2015. Urmylation and tRNA thiolation functions of ubiquitin-like Uba4.Urm1 systems are conserved from yeast to man. FEBS Letters 589, 904–909. https://doi.org/10.1016/j.febslet.2015.02.024
2014	Klassen, R., Kast, A., Wünsche, G., Paluszynski, J., Wemhoff, S., Meinhardt, F., 2014. Immunity factors for two related tRNAGlntargeting killer toxins distinguish cognate and non-cognate toxic subunits. Current Genetics doi 10.1007/s00294–014–0426–1. https://doi.org/10.1007/s00294-014-0426-1
2014	Scheidt, V., Jüdes, A., Bär, C., Klassen, R., Schaffrath, R., 2014. Loss of wobble uridine modification in tRNA anticodons interferes with TOR pathway signaling. Microbial Cell 1, 416–424. https://doi.org/10.15698/mic2014.12.179
2014	Kast, A., Klassen, R., Meinhardt, F., 2014. rRNA fragmentation induced by a yeast killer toxin. Molecular Microbiology 91, 606–617. https://doi.org/10.1111/mmi.12481
2014	Schaffrath, R., Abdel-Fattah, W., Klassen, R., Stark, M., 2014. The diphthamide modification pathway from Saccharomyces cerevisiae – Revisited. Molecular Microbiology 94, 1213–1226. https://doi.org/10.1111/mmi.12845
2012	Meineke, B., Kast, A., Schwer, B., Meinhardt, F., Shuman, S., Klassen, R., 2012. A fungal anticodon nuclease ribotoxin exploits a secondary cleavage site to evade tRNA repair. RNA 18, 1716–1724.
2012	Satwika, D., Klassen, R., Meinhardt, F., 2012. Anticodon nuclease encoding virus-like elements in yeast. Applied Microbiology and Biotechnology 96, 345–356.

Other Research Activities

2009	Post-Doc/Research Scientist I, UTMB (Texas, USA) Stay abroad
0	Additive actions of 5-fluorocytosine and fluconazole in resistant yeast strains Poster presentation
0	Additive actions of 5-fluorocytosine and fluconazole in resistant yeast strains Poster presentation
0	DNA repair pathways contribute to resistance against translational inhibitors in yeast Poster presentation
0	Evidence for additional permeases involved in the toxicity of the antifungal agent 5-fluorocytosine (5-FC) in Saccharomyces cerevisiae Poster presentation
0	Killer toxins of Kluyveromyces lactis and Pichia acaciae: mating inhibition and mating type control Poster presentation
0	Microbial linear plasmids. Microbiology Monographs, Vol. 7 (2007). Springer Verlag, Berlin Heidelberg Publisher activity
0	Novel yeast killer toxins mediate cell cycle arrest during S-phase and activation of the DNA damage checkpoint kinase Rad53 Poster presentation
0	The killer element pPin1-3 of the yeast Pichia inositovora. Poster Poster presentation
0	The Pichia acaciae killer system: Genetic analysis of toxin immunity Poster presentation