Journal article
Electric Field-Driven Disruption of a Native beta-Sheet Protein Conformation and Generation of a Helix-Structure
Publication Details
Authors: | Ojeda May, P.; Garcia, M. |
Publication year: | 2010 |
Journal: | Biophysical Journal |
Pages range : | 595-599 |
Journal acronym: | Biophys. J. |
Volume number: | 99 |
Start page: | 595 |
End page: | 599 |
ISSN: | 0006-3495 |
eISSN: | 1542-0086 |
Abstract
We demonstrate that an external constant electric field is able to modify the secondary structure of a protein and induce a transition from a beta-sheet into a helix-like conformation. This dramatic change is driven by a global rearrangement of the dipole moments at the amide planes. We also predict electric-field-induced modifications of the intermediate states of the protein.
We demonstrate that an external constant electric field is able to modify the secondary structure of a protein and induce a transition from a beta-sheet into a helix-like conformation. This dramatic change is driven by a global rearrangement of the dipole moments at the amide planes. We also predict electric-field-induced modifications of the intermediate states of the protein.
